Both fluorodeoxyglucose- and methionine-positron emission tomography demonstrated no uptake in the residual tumors. Posttreatment magnetic resonance imaging showed reduction of the tumors. The patient underwent 3 courses of combination chemotherapy using a standard dose of carboplatin and etoposide and 23.4 Gy of concurrent craniospinal irradiation. The authors report a case of multiple craniospinal germinomas in a DS patient who presented with bilateral oculomotor and facial nerve palsy and hearing loss.
In this paper, a rare case of multiple craniospinal germinomas in a patient with DS, which was successfully treated with standard-dose chemotherapy combined with craniospinal irradiation, is reported. The standard treatment for these patients with cancer has not yet been established, and the risks of standard chemotherapy are unclear. Patients with Down syndrome (DS) are more likely to develop chemotherapy-related complications. Miyake, Yohei Adachi, Jun-Ichi Suzuki, Tomonari Mishima, Kazuhiko Sasaki, Atsushi Nishikawa, Ryo The availability of CT-based three-dimensional treatment planning provided the capability of identifying the previously irradiated volume as a three-dimensional anatomic structure and of designing a highly customized set of treatment beams that minimized reirradiation of that volume.Ĭraniospinal Germinomas in Patient with Down Syndrome Successfully Treated with Standard-Dose Chemotherapy and Craniospinal Irradiation: Case Report and Literature Review. Craniospinal radiotherapy and a three-field pineal boost for trilateral retinoblastoma were delivered to a patient previously irradiated for ocular retinoblastoma. Bentel, Gunilla Sherouse, George W.Ī case study is presented. Craniospinal Irradiation for Trilateral Retinoblastoma Following Ocular Irradiation
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